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An Allosteric Signaling Pathway of Human 3-Phosphoglycerate Kinase from Force Distribution Analysis

Figure 5

Force distribution in hPGK.

Network-like representation of significant changes in inter-atomic forces. Red edges connect residue pairs having inter-atomic forces with |ΔFij| >90 pN. Red spheres indicate the substrate binding residues. BPG and ADP are denoted with purple sticks while Mg-ion is marked as a purple sphere. The orange spheres mark the two hinge points Glu192 and Gly394.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1003444.g005