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Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect Tumourigenicity
Figure 4
Three different examples of simulations resulting from the computational model. Each simulation represents one of the typical outcomes.
Each begins with a single TIC seeded in the middle of the computational domain. In each situation the phenotype parameters are slightly different, resulting in (A) An unsustainable tissue (parameters: 
, 
, 
and 
day), (B) A homeostatic tissue where the balance of stem cell renewal and progenitor proliferation leads to a tissue whose overall size remains relatively constant over time, possibly representing a dormant tumor (parameters: 
, 
, 
and 
day) and, (C) Neoplastic-like tissue where the tissue overgrows the computational domain (parameters: 
, 
, 
and 
day). On the right of the final time point, we have shown an example of the oxygen tension in the computational domain. n.b. these images are zoomed in to illustrate detail and do not represent the entire computational domain.
doi: https://doi.org/10.1371/journal.pcbi.1003433.g004