Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect Tumourigenicity
Figure 2
Differential phenotypes in cultures enriched for brain tumour initiating cells.
Bright field images of CD133+ patient derived glioblastoma cell lines cultured in Neurobasal supplemented with EGF, FGF and B27, exhibiting striking phenotypic variability. These differences highlight the heterogeneity present even in a highly controlled static environment between cells that are putatively the same.