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Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect Tumourigenicity

Figure 1

Cartoon representing the hierarchical model of stem-cell driven tissues.

In this formulation, each stem can undergo two types of division, either symmetric (with probability ) or asymmetric (with probability ). Each subsequently generated transient amplifying cell (TAC) can then undergo a certain number () of round of amplification before differentiating into a terminally differentiated cell (TD) which will live for a certain amount of time before dying ( timesteps). It is these three parameters, which we assume are intrinsic to a given stem cell, which we explore in this paper.

doi: https://doi.org/10.1371/journal.pcbi.1003433.g001