Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics
Figure 7
Kaplan-Meier survival analysis of the time without anemia after starting thiopurine therapy in very high TPMT activity patients versus other TPMT activity patients.
TPMT: thiopurine S-methyltransferase. Analysis based on biological test results. Anemia was censored for hemoglobin test results below 9 g/100 mL. All events occurring within the first week after starting thiopurine therapy were excluded from the analysis. Follow-up was censored after 360 days. A log-rank test was used for this analysis.