Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics
Figure 4
Manhattan plot of −log10 (P-values) for the 771 ICD-9-CM based aggregated codes between very high TPMT activity patients and other TPMT activity patients.
ICD-9-CM: International classification of diseases 9 clinically modified; TPMT: thiopurine S-methyltransferase. The dotted line represents a P-value of 0.05 and the dashed line represents the FDR corrected level of significance for q = 0.2.