A Unified View of “How Allostery Works”
Figure 4
The classification of allosteric ligands with ATSM.
Given an experimental sigmoid response-concentration curve with full biological response, we can determine the three independent parameters ,
, and
in ATSM. Full agonist, corresponding to
, produces a full biological response. Partial agonist even at saturating concentration can only produce a partial biological response with
. Inverse agonist suppresses basal activity with
. Neutral antagonist with
does not impose any biological response.