Electrodiffusive Model for Astrocytic and Neuronal Ion Concentration Dynamics
Figure 7
Sensitivity of (maximal extracellular
in the input zone) to variation in selected model parameters. (A) Sensitivity to input flux density (
) and the output rate constant (
). Similar values of
were obtained for the three marked data points: (i) black:
,
(default conditions), (ii) green:
,
, and (iii) red:
,
. B–D) Sensitivity to the length of the input zone (
), and tortuosities in the ECS (
) and ICS (
). (E–H) Sensitivity of
and
(baseline extracellular
) to membrane conductances (
,
and
), and the maximal Na+/K+-pump rate (
).
. (B–H) The legend applies to all panels. Black (i), red (ii) and green (iii) lines correspond to the input-parameter combinations marked in (A).