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Modeling the Afferent Dynamics of the Baroreflex Control System

Figure 9

Simultaneous response with a linear and a nonlinear BR model.

(A) Predictions obtained estimating one parameter set for all four pressure step-increases using the linear model with two Voigt bodies . Note, that the overshoot is diminished for responses to smaller step-increases in pressure, and that the baseline firing rate is not reproduced accurately. (B) Predictions obtained with the nonlinear model accounting for nonlinear stiffening with increased pressure allowed us to accurately fit all four responses using one set of parameter values.

doi: https://doi.org/10.1371/journal.pcbi.1003384.g009