Assessing Computational Methods for Transcription Factor Target Gene Identification Based on ChIP-seq Data
Figure 2
Evaluation of target scoring methods using genomic expression data.
Overlap of the top 500 targets with the top 500 genes differentially expressed in (A) HemoChIP and (B) ESChIP TF perturbation experiments. Overlap of the top 500 targets with the top 500 genes differentially expressed (C) between erythroid and myeloid cells or (D) between undifferentiated (ES) and differentiated (MEF) cells. Distributions of those normalized values are shown.