Structure-Based Function Prediction of Uncharacterized Protein Using Binding Sites Comparison
Figure 3
Similar evolutionary patterns in nucleotide binding sites found in PDB using ProBiS.
Predicted Tm1631 binding site (left) is similar to (right): (a) active site in DNA binding site of polymerase X (2w9m) with DNA ligand that was transposed from homologous protein structure 3au6; (b) allosteric site in uridine monophosphate kinase (2jjx); (c) active site of DNA-glycosylase (3fhf) with DNA ligand transposed from homologous protein structure 3knt.