Mapping the Structural and Dynamical Features of Kinesin Motor Domains
Figure 6
Dynamically coupled networks for ATP-like and ADP-like conformations.
Molecular figures (A and B) highlighting communities (composed of clustered edges – representing residues) for ATP and ADP states respectively. Red spheres indicate residues that occur in a majority of shortest paths connecting nodes in different communities (i.e. residues important for the connection between communities). (C and D) Community network representation (colored as in A and B). Each node (circle) represents a community with its grouped protein regions labeled. The width of connecting lines is proportional to the number of shortest paths passing through corresponding junctions (i.e. their betweenness values). The pathway connecting nucleotide binding switch regions to the neck-linker in the ATP-like conformation graph is highlighted in red. Abbreviations: L = loop, cm = conserved motif, nt = n-terminal, ct = c-terminal.