Exploring the Composition of Protein-Ligand Binding Sites on a Large Scale
Figure 2
Frequencies of solvent-accessible SC with a cutoff of SASA ≥5 Å2 and SASA ≥0.5 Å2.
Residues are sorted by decreasing hydrophobicity. With the smaller cutoff, the pattern shifts to more hydrophobic residues because poorly exposed, interior residues are able to meet the criteria with only a small patch of exposed surface.