Conformational Changes in Talin on Binding to Anionic Phospholipid Membranes Facilitate Signaling by Integrin Transmembrane Helices
Figure 6
Coarse-grained simulations of a talin/integrin TM complex with a lipid bilayer (simulation αβ-talh2-CG; see Table 1).
A. The initial state of the αβ-talh2-CG simulation. B. Relative movement of the domains of the talin/αβ complex during the αβ-talh2-CG simulation. Displacements of all the Cα atoms of the F0 (purple), the F1 (green), the F2 (cyan), the F3 (yellow) and β subunit (red) during the simulation are shown as arrows. The arrows are mapped onto the initial structure and the length of each arrow represents the displacement/direction of the corresponding Cα atom. C. Movement of the integrin TM region observed in the αβ-talh2-CG simulation. The β subunit is shown in red and the α subunit in blue. The key residues in the IMC and OMC regions are also shown.