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Conformational Changes in Talin on Binding to Anionic Phospholipid Membranes Facilitate Signaling by Integrin Transmembrane Helices

Figure 5

Simulation of the association of talin with a lipid bilayer (tal-h2F0-CG; see Table 1).

Distance between the centers of mass of talin and a lipid bilayer as a function of time for the simulation tal-h2F0-CG with an anionic (POPC/POPG) lipid bilayer. The different colored lines correspond to the five repeat simulations. The horizontal broken line indicates the distance observed when talin is associated with the bilayer surface.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1003316.g005