Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity
Figure 7
A summary of the highlighted potential target-target interactions.
(A) The profile of target-target interaction is visualized with a matrix, in which each row and column represents a target and a family of ligands, respectively. The color of each cell represents the significance level of related target-target interaction. If a pair of targets are known to share ligands in DrugBank, their interaction (grey colored) would not be considered. (B) Potential interactions are broadly observed between antipsychotic drugs and cardiac ion channels. (C) & (D) The ligands of COX-1 (p = 3.08×10−3) and COX-2 (p = 1.02×10−3) generally show high LOI to estrogen receptor beta (i.e. ERβ).