Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity
Figure 6
Identifying of target-target interactions by gene-expression similarity.
(A) In some cases, the ligands of one target may generally show high LOI to another distant target. (B) The OPRD1 ligands (positive set) collectively show higher LOI to CACNA1C than other compounds (negative set). Setting the LOI corresponding to 90 percent specificity as threshold, we find that all OPRM1 ligands are above the threshold (p = 1.08×10−5).