Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity
Figure 3
Receiver operating characteristic (ROC) curve is used to evaluate the performance of BAES score and unadjusted CMap expression similarity.
For the classification between compound pairs sharing target (positive set) or not (negative set), the area under curve for BAES and unadjusted CMap is 0.66 and 0.59, respectively. The advantage of BAES is verified with 2000 replicates of bootstrap test, by the pROC package for R (http://cran.r-project.org/web/packages/pROC/).