Dynamic Rendering of the Heterogeneous Cell Response to Anticancer Treatments
Figure 7
In silico experiments, exploring the consequences of default of specific checkpoints.
(A) Simulated growth curve in the absence of perturbations in descendants (red line) compared to the best fit final model (black line) and proliferation in untreated cells (green line). (B) Growth curve in the final model (black line), in the presence of an additional agent (drug A) increasing the probability of G1 block (p = 0.8) (red line) and with an additional agent (drug B) preventing exit from G2M block (green line).