Dynamic Rendering of the Heterogeneous Cell Response to Anticancer Treatments
Figure 5
Dynamic rendering t of proliferation after X-ray exposure.
Cell distributions in the cell cycle and over generations are shown at representative times (24 h and 72 h) and doses (ctrl, 0.5 and 5 Gy). The whole time courses for all doses (the final best fit model) are reported as Supplementary Videos. The plots shows the density of cycling cells in G1 (red dots in the inner sector), S (green, intermediate sector) and G2M (blue, external sector) phases according to their age (progressing clockwise from the starting point of each phase). The whole cycle lasts 24 h. The S and G2M starting points are placed in the figures at points corresponding to the mean duration of the previous phase, and are preceded by a compartment collecting quiescent cells. G1 blocked cells are presented as red dots in the intermediate sector, before the starting point of S phase, G2M-blocked cells are blue dots at the end of the cycle, external to the G2M sector. Polyploid cells are presented as black dots in a sector placed to the upper right of the cycle.