Dynamic Rendering of the Heterogeneous Cell Response to Anticancer Treatments
Figure 4
Data and fit with the final model.
Time courses of measurable quantities obtained from the final model compared with experimental data (symbols), for each radiation dose. The good quality of the fit indicates that the model successfully predicts FC and TL data of all doses at the same time. a) Time course of %G1, %S, %G2M; b) percentage of residual undivided BrdU+ cells (supplementary Text S1); c) number of cells in gen0 (g0), gen1 (g1), gen2 (g2), gen3 and higher generations (g3+) and polyploid (pol), normalized assuming N(0) = 1000; d) percentage of cells which died in the 0–72 h observation time among cells entered in each generation. The symbols and error bars represent the mean and standard deviation of experimental data of at least three independent experiments (FC) or five replicate culture wells (TL).