Properties of MHC Class I Presented Peptides That Enhance Immunogenicity
Figure 4
Predicting Dengue-derived CTL epitopes with the immunogenicity model.
Immunogenicity scores were determined for non-redundant epitopes (n = 22) and non-epitopes (n = 110) identified in mice by Weiskopf et al. [55] (A), and for non-redundant epitopes (n = 42) and non-epitopes (n = 477) identified by Weiskopf et al. in humans [56] (B). Average and variation of the average are shown as thick lines with error bars, individual scores are shown as dots. Both in mice and in men, the epitopes had a significantly higher immunogenicity score than the non-epitopes (Murine data (A): p<0.01 (Wilcoxon rank-sum test); AUC = 0.69. Human data (B): p = 0.014 (Wilcoxon rank-sum test); AUC = 0.61).