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A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

Figure 13

Whether neurons in large LPZs recover depends on the growth parameters and .

A) Network repair of large LPZs does not occur for low and high , although some network reorganization takes place in the peri-LPZ and the border of the LPZ. B) Even in large LPZs neurons can completely recover if both and are low and the remaining activity in the LPZ allows axonal and dendritic elements to increase in number. Bars next to the top right panel indicate the size and position of the LPZ (orange and blue) and the peri-LPZ (green) relative to the entire network. Total number of neurons (excitatory and inhibitory): LPZ: 328 neurons; peri-LPZ: 72 neurons.

doi: https://doi.org/10.1371/journal.pcbi.1003259.g013