A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

doi:10.1371/journal.pcbi.1003259

A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

Figure 10

Network repair is not obtained if the minimum activity required for the formation of dendritic elements is higher than the activity inside the LPZ after the lesion.

A) In this scenario with , new synaptic connections impinging on neurons in the LPZ are formed only transiently in the early phase after the lesion when the activity of some neurons momentarily exceeds . New connections are removed over time and even old connections are pruned. B) Activity in the LPZ decreases to a minimum level over time. Cf. Fig. 3 for color code.

doi: https://doi.org/10.1371/journal.pcbi.1003259.g010