A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

doi:10.1371/journal.pcbi.1003259

A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

Figure 7

The model shows a significant overshoot in axonal elements on excitatory neurons over time following a lesion, as compared with the control situation without a lesion.

A) The overshoot in the model is caused by axonal elements from neurons in the peri-LPZ (green line; brown: control). All measurements are averaged over runs; error bars: SD. B) Although the available experimental data is very limited, there are two examples from an anterograde tracer study (labeling neurons in the peri-LPZ and measuring windows in the LPZ) in monkeys after focal retinal lesions that show a clear overshoot in axonal bouton densities of excitatory neurons. Green squares indicate points of measurement. Modified from [13].

doi: https://doi.org/10.1371/journal.pcbi.1003259.g007