A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions
Figure 6
The dynamic changes in dendritic elements in the structural plasticity model show remarkable similarities to the spine dynamics in the visual cortex of mice after focal retinal lesions.
The figure shows the survival fraction rates, accumulative addition rates and turnover rates of dendritic elements and dendritic spines on excitatory neurons A) in the model and B) in the experiment (experimental data in B reprinted by permission from Macmillan Publishers Ltd: Nature Neuroscience: Keck T et al. (2008) Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci 11:1162–1167, copyright 2008). Error bars in A) SD and in B) (experimental data:) SEM with center of LPZ: cells; border of LPZ:
cells; control:
cells. Color code: center of the LPZ: blue; border of the LPZ: orange; control: brown.