A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions
Figure 4
Local growth rules give rise to a change in the number of axonal and dendritic elements, which is crucial for network repair.
Net changes are measured as loss or gain in A) axonal and B) dendritic elements on excitatory neurons between two time steps divided by the initial number of synaptic elements before the lesion. Also shown are the average number of synaptic elements per excitatory neuron. C) Total number of excitatory synapses impinging on excitatory neurons in the peri-LPZ, in the border and in the center of the LPZ. D) Increase in average electrical activity (represented by calcium concentration) over time of all neurons in the peri-LPZ, in the border and in the center of the LPZ. All measurements for the peri-LPZ are labeled green, for the border orange, for the center blue and for controls brown. All measurements are averaged over runs; error bars: SD. Bars in (A) indicate the early, middle and late phase after lesion.