Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks
Figure 6
Interplay of transcription factors and signaling proteins in specifying the regulatory programs of modules.
A. Shown are the fraction of modules that are regulated by TFs alone, signaling proteins alone or both B. Shown are the co-regulatory, genetic and protein-protein interactions between regulators associated with HOG1 associated modules. HOG1 is a protein kinase involved in osmotic stress and cell wall organization. HOG1 is predicted to be a regulator for Modules 2 and 37, and is known to be directly upstream of SKO1 which is predicted to regulate genes in Module 19. Co-regulatory relations are inferred between two regulators if they share common targets. Genetic and protein-protein interactions are obtained from BioGRID [66].