< Back to Article

Mechanistic Model of Natural Killer Cell Proliferative Response to IL-15 Receptor Stimulation

Figure 4

The quantitative influence of intermediate affinity binding model parameters on the steady state cell surface receptor and complex numbers.

Model simulations were performed with the value of the parameter of interest varied by a factor of , , , , , , 10, 33, and 100, while the values of all other parameters were held constant. Changes in cell surface receptor and complex numbers as a result of variations in parameter values are shown. Receptor and complex numbers corresponding to different values of the parameter of interest are shown by the dashed curves (with the arrow representing increasing values of the parameter being varied) while the solid curves represent the parameters at their original values. Simulations were performed for model parameters k_f (A), k_r (B), k_f and k_r (C), k_endo (D), k_int (E), k_s (F), and k_syn (G) at an IL-15 concentration of 25 ng/ml. Large increases (>10-fold) in k_syn resulted in large perturbations in receptor and complexes numbers (data not shown).

doi: https://doi.org/10.1371/journal.pcbi.1003222.g004