Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model
Figure 5
Temperature dependence of ChR2 current.
A–D Experimental data, adapted from [30], showing the effect of temperature (22°C and 37°C) on τON, τINACT, τOFF and ISS/IP for a range of voltages. E. Temperature scaling factors (Q10 values), derived from the data in A–D. F. Summary of average Q10 values (from E) used as constraints for the model optimization; optimized Q10 values for the rate parameters of the model. G. Example model traces of ChR2 current for the specified voltage and irradiance values at 22°C and 37°C.