Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model
Figure 4
Kinetics of recovery from inactivation for ChR2 in experiments (left) and in the model (right).
AB. Experimental and model traces in response to S1–S2 protocol, 3 s inter-pulse interval, irradiance of 1.6 mW/mm2 and holding voltages of −40 and −80 mV. CD. Light dependence of τR across four voltage values. EF. Voltage dependence of τR across three irradiance levels. GH. Ratio of the peak currents in response to S2 and S1, IP2/IP1, as function of inter-pulse interval, across four voltage values. IJ. Ratio of the peak currents in response to S2 and S1, IP2/IP1, as function of inter-pulse interval, across three irradiance levels. Experimental data in C and E were fits to the average curves, n = 4. Experimental data in G and I are presented as mean±S.E., n = 4.