Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
Figure 9
Effects of simulated perturbations of the putative closed/cyclic core destruction complex.
Three cases are considered, as indicated in the descriptions of Text S8, S9, S10 (Supporting Information). Each of the three protein-protein interfaces, (Text S8),
(Text S9), and APC-Axin (Text S10), is ablated such that a closed/cylic structure cannot form. The relative
level in each case is compared with the nominal
level in a normal cell.