Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
Figure 8
Sequestration of away from Axin by APC1338.
(A) Predicted amount of associated either directly or indirectly with Axin is shown as a function of APC1338 concentration in the background of an SW480 cell. The horizontal axis indicates the amount of APC1338 divided by the nominal amount of APC1338 in an SW480 cell (100 nM). The vertical axis indicates the amount of Axin-associated
divided by the total amount of
at steady state, which is a function of APC1338 concentration. (B) Predicted amount of
associated either directly or indirectly with Axin is shown as a function of full-length APC concentration in the background of a normal cell. The horizontal axis indicates the amount of full-length APC divided by the nominal amount of full-length APC in a normal cell (100 nM). The vertical axis indicates the amount of Axin-associated
divided by the total amount of
at steady state, which is a function of full-length APC concentration. (C) Predicted amount of
associated directly with APC1338 as a function of relative APC1338 concentration. (D) Predicted amount of
associated directly with full-length APC as a function of relative full-length APC concentration. All results shown were obtained using the parameter values of Table 1, except as indicated. The following BioNetGen input files were used to obtain simulation results: Text S3 was used for panels A and C and Text S2 was used for panels B and D.