Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
Figure 7
APC1338 phosphorylation and its competition with Axin for .
(A) level is shown at different levels of APC1338 phosphorylation. Phosphorylation of APC1338 at the first 20-aa repeat is modulated by changing the values of the phosphorylation and dephosphorylation rate constants
and
. In the figure, the ratio,
corresponds to the default values of
and
in the model, which are taken to be the same (Table 1). The case where
represents an extreme, where the 20-aa repeat always remains phosphorylated. The case where
represents the opposite extreme, where APC1338 never becomes phosphorylated. (B) Competition effects on
binding arising from APC1338 phosphorylation. The
represents the fraction of Axin in complex with
. The patterns of the lines represent different phosphorylation and dephosphorylation rate constants, as labeled in panel A. The simulation results shown here were obtained using Text S3, a BioNetGen input file provided in the Supporting Information.