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Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells

Figure 6

Concentration-dependent effects of APC constructs in SW480 cells.

Predicted level is shown as a function of expression level for APC-B, -C, -D, and -E. In each panel, the represents the amount of expression relative to the endogeneous level of APC1338 (100 nM). The represents the level relative to the nominal level in a normal cell (35 nM, Table 1). Thus, a value of 1 on the corresponds to a concentration of 100 nM of transfected protein, and a value of 1 on the corresponds to a concentration of 35 nM of . The simulation results shown here were obtained using BioNetGen input files provided in the Supporting Information: Text S3 was used for panel A, Text S5 was used for panel B, Text S6 was used for panel C, and Text S7 was used for panel D.

doi: https://doi.org/10.1371/journal.pcbi.1003217.g006