Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
Figure 5
Concentration-dependent effects of full-length APC on .
(A) level in a normal cell is shown as a function of APC concentration. The
represents the relative amount of APC introduced exogeneously with respect to the endogeneously present 100 nM of full-length APC in a normal cell. The
represents the level of
relative to its nominal level in a normal cell (Table 1). (B)
level in an SW480 cell is shown as a function of APC concentration. The
represents the amount of APC introduced exogeneously relative to the endogeneously present 100 nM of APC1338 in an SW480 cell. The
represents the level of
relative to its nominal level in a normal cell, as in panel A. The simulation results shown here were obtained using BioNetGen input files provided in the Supporting Information: Text S2 was used for panel A and Text S4 was used for panel B.