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Mammalian Rest/Activity Patterns Explained by Physiologically Based Modeling
Figure 6
Simulations and data for SCN lesions in the squirrel monkey.
Double-plotted raster plots of sleep/wake patterns are shown for (A) simulated intact animals and (B) simulated SCN-lesioned (SCNx) animals, with dark bars representing sleep (
s−1). Percentage of time spent awake as a function of circadian time is shown for (C) data (mean ± SEM), and (D) simulation, for both intact (open circles) and lesioned (filled squares) animals. Circadian time is defined with respect to the 25.0-period of the intact animal, with 24 h of circadian time corresponding to one full circadian cycle. Circadian time zero is defined as the first bout with >50% average wake in the intact animal. Spectral amplitudes (normalized to an area of 1) are plotted versus period for (E) Drinking patterns in the intact animal, (F) 
in the simulated intact animal, (G) Drinking patterns in the SCN-lesioned animal, (H) 
in the simulated SCN-lesioned animal. Note that the model uses a higher sampling rate than data. The data in panels (C), (E), and (G) are adapted from [43] and manually replotted here.
doi: https://doi.org/10.1371/journal.pcbi.1003213.g006