Mammalian Rest/Activity Patterns Explained by Physiologically Based Modeling
Figure 4
Circadian and homeostatic processes in cooperative versus competitive networks.
The average waveforms (over 60 days) are shown for (A) cooperative and (B) competitive DMH/VLPO and DMH/LHA relays. Parameter values correspond to (A) and (B) in Figure 3, respectively. In each panel, we show the average waveform of the homeostatic drive for sleep (gray line), as well as the average waveforms of the circadian drives for wakefulness to both the VLPO via the DMH (black solid line) and the MA via the DMH/LHA (black dashed line). More positive values of the circadian drives for wakefulness correspond to greater inhibition of VLPO and greater excitation of MA for the DMH/VLPO and DMH/LHA relays, respectively. Panel (C) shows a double-plotted raster diagram of sleep (dark bars) over 60 days for the competitive case in panel (B).