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Mammalian Rest/Activity Patterns Explained by Physiologically Based Modeling

Figure 3

Cooperation and competition between DMH/VLPO and DMH/LHA relays result in unimodal and bimodal activity patterns, respectively.

Simulated MA firing rate, , for a primate under a LD cycle, with 500 lux for 6–18 h and 0 lux for 18-6 h (shaded). The DMH/LHA pathway is (A) excitatory (i.e., cooperative), or (B) inhibitory (i.e., competitive). (C) The averaged activity patterns of a spider monkey living in the wild; the data are adapted from [12] and replotted manually here. Simulations and data are averaged in 5 min non-overlapping windows over 60 days and double-plotted.

doi: https://doi.org/10.1371/journal.pcbi.1003213.g003