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Mammalian Rest/Activity Patterns Explained by Physiologically Based Modeling
Figure 2
SPZ modulation of SCN output yields a spectrum of nocturnal to diurnal phenotypes.
Model simulations of rodent sleep/wake patterns are shown for different values of the modulation parameter 
, which takes values from −1 (nocturnal) to 1 (diurnal) going from left to right. The simulated rodent was under a 24-h light/dark cycle with 12 h of 100 lux followed by 12 h of 0 lux. Panels (A)–(E) show the MA firing rate, 
, across a 24-h period (blue) and averaged across this period in 10-min non-overlapping windows (black). Wakefulness is defined as 
s−1. Panels (F)–(J) show arousal state across a 24-h period (red), with high values corresponding to wake and low values corresponding to sleep, as well as average percentage wakefulness (black), averaged across 30 days in 10-min non-overlapping windows.
doi: https://doi.org/10.1371/journal.pcbi.1003213.g002