Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides
Figure 5
Representative structures of super structural families for each IAPP variant.
Standard deviation was calculated from the last 3 blocks of the simulation data (100 ns of each) at 300 K (See Figures S2 for all structural families in each super family from the last block). The backbone is shown in cartoon and the secondary structure is coded by color: coil in silver, β-sheet in yellow, isolated β-bridge in tan and turn in cyan. The N-terminus is indicated by a red ball.