How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
Figure 6
Model of OS cell proliferation.
The picture illustrates the proposed model of OS cell proliferation co-regulated by miR-9-5p, miR-138, and miR-214 and the TFs SP1 and MYC. These regulators control mainly components of the NFKB- and RB1-pathway and of focal adhesion processes. Primary microRNA targets are rectangular and secondary targets are ellipse shaped. Red marks up-regulated genes in proliferative active OS cell lines and green indicates down-regulated genes. White nodes represent genes not DE in OS cell proliferation. Solid and dashed arrows illustrate direct and indirect functional associations, respectively. RB1 is shaded in red to indicate that it is no member of the global networks.