How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
Figure 4
MicroRNA and TF co-regulatory motifs.
Schematic illustration of (A) 3-node and (B) 4-node FFL motifs. A 3-node motif contains a microRNA, a TF, and a commonly regulated target gene. In contrast, 4-node FFLs comprise a microRNA, a TF, a microRNA target gene (primary target), and a TF target gene (secondary target) that interacts with the primary target. MicroRNAs are indicated with diamonds, TF with triangles, primary targets with rectangles, and secondary targets with circles. (C) Coexpression of microRNA and TF target genes. The plot shows the observed and random cumulative distribution functions (CDFs, y-axis) of the Pearson correlation coefficients (x-axis) between any gene pair regulated by a specific microRNA and TF 3-node and 4-node motif. The observed and random CDFs are compared using the KS test. The p-values are indicated within the plots. Green and orange color codes correspond to the distinct clusters C1 and C2.