Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs
Figure 7
Combined view of the three optimal subgraphs resulting when adding TGFα to CREB to the initial model structure.
In all three solutions, the edges erk12→p70s6_1, tgfa→stat3, p90rsk→creb and p38→creb are removed. Edges tgfa→mek12 and rac_cdc42→mek12 represent alternative pathways; at least one of both must be contained.