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Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs

Figure 6

Discretized data and the (two) SCEN_FIT solutions that result from the optimal subgraphs given in Figure 5.

The color coding is the same as in Figure 3. All six optimal subgraphs contained in Figure 5 give rise to the same SCEN_FIT solution, except for the CREB column. Here, three subgraphs show a mismatch in scenarios 5, 10, and 15 (indicated by the left semicycles), while the other three show a mismatch in scenarios 6, 11, and 16 (indicated by the right semicycles).

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1003204.g006