Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis
Figure 1
Stochastic channel gating contributes to BVR in a computational model of the canine ventricular myocyte.
A. 5 consecutive APs in a representative canine ventricular midmyocardial cell, the deterministic computational model, or the model with a stochastic Markov formulation of IKr (top to bottom) at 1000-ms pacing CL. APD (ms) is indicated below each beat. B. Poincaré plot of 45 consecutive APDs for the conditions in (A). The white circle in each panel indicates the steady-state APD of the deterministic model.