Using Biological Pathway Data with Paxtools
Figure 2
A plausible signaling path (yellow) between the androgen receptor (AR, top) and the TP53 protein (p53, right) is found by a Paxtools “paths-between” query and visualized in the Chisio BioPAX Editor.
These cross-talks are difficult to find manually without a graph search because of the large number of connections to/from AR and p53 and because of fragmentation of data across multiple pathway data sources.