A General Model for Toxin-Antitoxin Module Dynamics Can Explain Persister Cell Formation in E. coli
Figure 3
The levels of antitoxin and toxin-antitoxin complexes decrease with increasing number of operator binding sites.
(A) Probability density functions (p.d.f) for free antitoxin, free toxin, free complex AT and free complex TAT using the generic model with independent binding sites on the operator are shown. refers to the probability of finding the species
(where
can be
,
,
or
) with a given amplitude. The gray-shaded region shows the margin of error with width 2
, the dark gray line shows the mean. (B) Mean value of protein level versus the reciprocal number of binding sites on the operator (
). No toxic feedback effects are included:
.