Endogenous Cholinergic Inputs and Local Circuit Mechanisms Govern the Phasic Mesolimbic Dopamine Response to Nicotine
Figure 7
Temporal dynamics of GABA and DA neuron activity in response to 1 µM nicotine in case α4β2 receptor desensitization is driven by Nic and ACh.
(A,C) GABA (A) and DA (C) neuron activity in the direct stimulation case (same as in Fig. 4C,E full blue lines; ,
µM,
,
) for different efficacies of ACh to drive α4β2 receptor desensitization (η given in panel A). (B,D) GABA (B) and DA (D) neuron activity in the disinhibition case (
,
µM,
,
) for different efficacies of ACh to drive α4β2 receptor desensitization (η given in panel B, see Models).