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Ultrasensitivity in Phosphorylation-Dephosphorylation Cycles with Little Substrate

Figure 1

The ratio of the concentration of kinases to the concentration of their substrates does not appear biased in S. cerevisiae.

(A) The distribution of kinase saturation levels, (the ratio of kinase concentration to substrate concentration), for the phosphorylation reactions in the BioGRID database [18] with levels of gene expression during log phase growth in rich media measured by Ghaemmaghami et al. [19]. The data contains 2850 phosphorylation reactions, comprising 98 unique kinases and 1136 unique substrate targets. (B) Equivalent distribution for phosphatases. The data contains 43 dephosphorylation reactions, comprising 16 unique phosphatases and 32 unique targets.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1003175.g001